a Record control number WOS:000272929900008

a ISSN 0954-691X

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WI 140

b Item number .D6 2010

a Personal name Kurt, Mevlut.

h Medium Electronic Document

a Title Do metabolic alterations serve as biochemical markers in the diagnosis of malignant biliary obstruction? An observational study

c Statement of responsibility, etc Mevlut Kurt, Ibrahim K. Onal, Erkan Parlak, Ali Shorbagi, Murat Kekilli, Mehmet Ibis, Mutlu Hayran, Nurgul Sasmaz.

b Name of publisher, distributor, etc Lippincott Williams & Wilkins,

c Date of publication, distribution, etc 2010.

a Summary, etc Objectives The aim of this study was to investigate the changes in serum lipid profiles in biliary obstruction associated with benign and malignant conditions and to find whether they can be used as adjunctive biochemical tumor markers in the differential diagnosis.Methods One hundred and twenty patients (60 malignant, 60 benign) who underwent endoscopic retrograde cholangiopancreatography with the clinical picture of intrahepatic and extrahepatic cholestasis were reviewed in the period from January to July 2008.Results In the malignant group, significantly higher cholesterol (P<0.001), low-density lipoprotein (P<0.001), and triglycerides (P<0.001) were observed, whereas high-density lipoprotein (P<0.001) levels were lower. The receiver operating characteristic analysis showed that high-density lipoprotein 19.5 mg/dl or less [sensitivity: 88.3%, specificity: 83.3%, area under the curve: 0.906 (0.851-0.961), P<0.001] and total to -high-density lipoprotein cholesterol ratio at least 17.7 [sensitivity: 80.0%, specificity: 93.1%, area under the curve: 0.921 (0.871-0.971)] were strong predictors of malignant biliary obstruction.Conclusion Serum lipid profile may be used as an adjunctive marker to identify malignant causes of the obstructive jaundice. Eur J Gastroenterol Hepatol 22:58-60 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

a Topical term or geographic name as entry element Gastroenterology & Hepatology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

x International Standard Serial Number 0954691X

g Relationship information JAN 2010, Vol.22 Issue 1, p58-60

t Title European journal of gastroenterology & hepatology

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1097/MEG.0b013e32833036c3